(19)

(11)

EP 1 014 988 A2

(12)

(88) Date of publication A3: 19.08.1999 (43) Date of publication: 05.07.2000 Bulletin 2000/27 (21) Application number: 98924847.1 (22) Date of filing: 22.05.1998

(51) International Patent Classification (IPC)7: A61K 31/505 (86) International application number: PCT/US9810/505 (87) International publication number: WO 9852/514 (26.11.1998 Gazette 1998/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.05.1997 US 862382 (71) Applicants: HADASIT MEDICAL RESEARCH SERVICES &DEVELOPMENT CO., LTD. Jerusalem 91120 (IL) Agricultural Research Organization, Ministry of Agriculture Bet Dagan 50250 (IL)	(72) Inventors: PINES, Mark 76308 Rehovot (IL) NAGLER, Arnon 74381 Jerusalem (IL) (74) Representative: Wind, Jacques  CABINET JACQUES WIND47, rue Benoit BennierB.P. 30 69751 Charbonnières-les-Bains Cédex 69751 Charbonnières-les-Bains Cédex (FR)