(19)
(11) EP 1 015 577 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
04.10.2006 Bulletin 2006/40

(45) Mention of the grant of the patent:
23.11.2005 Bulletin 2005/47

(21) Application number: 98947108.1

(22) Date of filing: 11.09.1998
(51) International Patent Classification (IPC): 
C12N 15/10(1990.01)
 C12N 15/81(1990.01)
(86) International application number:
PCT/US1998/019448
(87) International publication number:
WO 1999/014320 (25.03.1999 Gazette 1999/12)

(54)

CHROMOSOMAL MUTAGENESIS IN PICHIA METHANOLICA

CHROMOSOMALE MUTAGENESE IN PICHIA METHANOLICA

MUTAGENESE CHROMOSOMIQUE DANS PICHIA METHANOLICA

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 15.09.1997 US 929748
30.12.1997 US 1141

(43) Date of publication of application:
05.07.2000 Bulletin 2000/27

(73) Proprietor: ZymoGenetics, Inc.
Seattle, WA 98102 (US)

(72) Inventor:
  • RAYMOND, Christopher, K.
    Seattle, WA 98115 (US)

(74) Representative: Lawrence, Malcolm Graham et al
HLBBshaw Merlin House Falconry Court Baker's Lane
Epping, Essex CM16 5DQ
Epping, Essex CM16 5DQ (GB)


(56) References cited: : 
WO-A-92/17595
 WO-A-97/17450
   
  • HIEP T T ET AL: "TRANFORMATION IN THE METHYLOTROPHIC YEAST PICHIA METHANOLICA UTILIZING HOMOLOGOUS ADE1 AND HETEROLOGOUS SACCHAROMYCES CEREVISIAE ADE2 AND LEU2 GENES AS GENETIC MARKERS" YEAST, vol. 9, 1993, pages 1189-1197, XP000653248 cited in the application
  • HIEP T T ET AL: "THE 5-AMINOIMIDAZOLE RIBONUCLEOTIDE-CARBOXYLASE STRUCTURAL GENE OF THE METHYLOTROPHIC YEAST PICHIA METHANOLICA: CLONING, SEQUENCING AND HOMOLOGY ANALYSIS" YEAST, vol. 9, 1993, pages 1251-1258, XP000653249
  • RAYMOND C K ET AL: "Development of the methylotrophic yeast Pichia methanolica for the expression of the 65 kilodalton isoform of human glutamate decarboxylase." YEAST, (1998 JAN 15) 14 (1) 11-23. JOURNAL CODE: YEA. ISSN: 0749-503X., XP002090804 ENGLAND: United Kingdom
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).