(19)

(11)

EP 1 015 602 A1

(12)

(43) Date of publication: 05.07.2000 Bulletin 2000/27 (21) Application number: 98904799.8 (22) Date of filing: 03.02.1998

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/10, C07K 16/40, C12Q 1/52 (86) International application number: PCT/US9801/860 (87) International publication number: WO 9833/925 (06.08.1998 Gazette 1998/31)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.02.1997 US 37275 P (71) Applicant: YALE UNIVERSITY New HavenCT 06520 (US)	(72) Inventor: SÖLL, Dieter Hamden, CT 06517 (US) (74) Representative: Mouget-Goniot, Claire et al Cabinet Orès,6, Avenue de Messine 75008 Paris 75008 Paris (FR)