(19)

(11)

EP 1 017 387 A1

(12)

(43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98949454.7 (22) Date of filing: 24.09.1998

(51) International Patent Classification (IPC)7: A61K 31/44, A61K 31/47, A61K 31/52, A61K 31/55, A61K 31/415, A61K 31/445, A61K 31/495, C07D 401/12, C07D 401/14, C07D 403/12, C07D 413/12, C07D 417/12, C07D 487/00 (86) International application number: PCT/US9819/949 (87) International publication number: WO 9915/170 (01.04.1999 Gazette 1999/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 24.09.1997 US 59832 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventor: MILLER, William, H. Schwenksville, PA 19473 (US) (74) Representative: Valentine, Jill Barbara et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)