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(11)

EP 1 017 393 A1

(12)

(43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98946835.0 (22) Date of filing: 03.09.1998

(51) International Patent Classification (IPC)7: A61K 31/495, C07D 241/20, C07D 401/12, C07D 401/14, C07D 405/12, C07D 405/14 (86) International application number: PCT/US9818/417 (87) International publication number: WO 9911/267 (11.03.1999 Gazette 1999/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.09.1997 US 58058 P 16.01.1998 GB 9801005 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: SANDERSON, Philip, E. Rahway, NJ 07065 (US) LYLE, Terry, A. Rahway, NJ 07065 (US) DORSEY, Bruce, D. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)