(19)

(11)

EP 1 017 437 A2

(12)

(88) Date of publication A3: 18.02.1999 (43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98909945.2 (22) Date of filing: 13.03.1998

(51) International Patent Classification (IPC)7: A61M 15/00 (86) International application number: PCT/SE9800/456 (87) International publication number: WO 9841/255 (24.09.1998 Gazette 1998/38)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV MK RO SI (30) Priority: 14.03.1997 SE 9700935 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: JENNINGS, Douglas Royston,Herts SG8 6DS (GB) JEPPSSON, Magnus S-22100 Lund (SE) (74) Representative: As Sivborg, Susanne Birgitta et al Astra AB,Intellectual Property, Patents 151 85 Södertälje 151 85 Södertälje (SE)