(19)

(11)

EP 1 017 699 A1

(12)

(43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98944338.7 (22) Date of filing: 18.09.1998

(51) International Patent Classification (IPC)7: C07D 499/18, C07D 501/12, C12P 37/04, C12P 35/04 (86) International application number: PCT/NL9800/539 (87) International publication number: WO 9915/532 (01.04.1999 Gazette 1999/13)

(84) Designated Contracting States: AT ES IT NL (30) Priority: 19.09.1997 NL 1007076 (71) Applicant: DSM N.V. 6411 TE Heerlen (NL)	(72) Inventors: BOESTEN, Wilhelmus, Hubertus, Joseph NL-6132 BJ Sittard (NL) MOODY, Harold, Monro NL-6211 BZ Maastricht (NL) GROOTEN, Hubertus, Maria, Jozef NL-6181 PE Stein (NL) (74) Representative: Jacobs, Monique S.N. et al DSM Patents & TrademarksOffice GeleenPostbus 9 6160 MA Geleen 6160 MA Geleen (NL)