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EP 1 017 719 A1

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(43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98949749.0 (22) Date of filing: 02.10.1998

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 14/00, C07K 7/00, C12N 5/10, C12N 15/11, C12N 15/12 (86) International application number: PCT/US9820/793 (87) International publication number: WO 9918/127 (15.04.1999 Gazette 1999/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.10.1997 US 942813 01.10.1998 US 165960 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)

(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) MCCOY, John, M. Reading, MA 01867 (US) LAVALLIE, Edward, R. Harvard, MA 01451 (US) RACIE, Lisa, A. Acton, MA 01720 (US) EVANS, Cheryl Woburn, MA 01801 (US) MERBERG, David Acton, MA 01720 (US) TREACY, Maurice Chestnut Hill, MA 02167 (US) AGOSTINO, Michael, J. Andover, MA 01810 (US) SPAULDING, Vikki Billerica, MA 01821 (US) (74) Representative: Dörries, Hans Ulrich et al FrohwitterPatent- und RechtsanwältePossartstrasse 20 81679 München 81679 München (DE)