(19)

(11)

EP 1 017 816 A1

(12)

(43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98942285.2 (22) Date of filing: 28.08.1998

(51) International Patent Classification (IPC)7: C12N 15/16, C07K 14/65, C12N 1/19, C12N 1/21, C12N 5/10, C07K 14/62, C12Q 1/68, C07K 19/00, G01N 33/74, C07K 16/26 (86) International application number: PCT/US9817/888 (87) International publication number: WO 9915/664 (01.04.1999 Gazette 1999/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.09.1997 US 59836 P (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)	(72) Inventor: GURNEY, Austin Belmont, CA 94002 (US) (74) Representative: Kremer, Simon Mark et al Mewburn Ellis,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)