(19)

(11)

EP 1 017 838 A2

(12)

(88) Date of publication A3: 10.06.1999 (43) Date of publication: 12.07.2000 Bulletin 2000/28 (21) Application number: 98946556.2 (22) Date of filing: 23.09.1998

(51) International Patent Classification (IPC)7: C12N 15/86, C12N 15/63, C12N 5/10, A61K 48/00 (86) International application number: PCT/GB9802/885 (87) International publication number: WO 9915/684 (01.04.1999 Gazette 1999/13)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.09.1997 GB 9720216 25.09.1997 GB 9720465 (71) Applicant: Oxford Biomedica (UK) Limited Oxford 0X4 4GA (GB)	(72) Inventors: LEWIS, Claire,University of Sheffield Sheffield S10 2RX (GB) BINLEY, Katie, Mary Headington,Oxford OX3 7XF (GB) BEBBINGTON, Chris Boxford,Newbury RG20 8DJ (GB) NAYLOR, Stuart Amersham,Bucks HP6 6AN (GB) (74) Representative: Harding, Charles Thomas et al D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)