(19)
(11) EP 1 018 559 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
28.11.2007 Bulletin 2007/48

(45) Mention of the grant of the patent:
29.08.2007 Bulletin 2007/35

(21) Application number: 99308902.8

(22) Date of filing: 09.11.1999
(51) International Patent Classification (IPC): 
C12N 15/55(2006.01)
C12Q 1/34(2006.01)
 C12N 9/16(2006.01)
C12Q 1/68(2006.01)

(54)

Phosphodiesterase enzymes

Phosphodiesterasen

Phosphodistérases

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 23.12.1998 GB 9828603
17.09.1999 GB 9922123

(43) Date of publication of application:
12.07.2000 Bulletin 2000/28

(73) Proprietors:
  • Pfizer Limited
    Sandwich, Kent CT13 9NJ (GB)
    Designated Contracting States:
    GB 
  • PFIZER INC.
    New York, N.Y. 10017-5755 (US)
    Designated Contracting States:
    AT BE CH CY DE DK ES FI FR GR IE IT LI LU MC NL PT SE 

(72) Inventor:
  • Fidock, Mark, c/o Pfizer Central Research
    Sandwich, Kent CT13 9NJ (GB)

(74) Representative: England, Peter Michael 
Pfizer Limited European Pharma Patent Department (I.P.C. 748) Ramsgate Road
Sandwich Kent CT13 9NJ
Sandwich Kent CT13 9NJ (GB)


(56) References cited: : 
WO-A-00/77226
US-A- 5 527 896
 WO-A-97/35989
   
  • Nucleotide sequence database EMBL ID AI006099, Accession number AI006099 15 June 1998 Mus musculus cDNA clone 1364394 5' similar to TR:Q13946 cAMP phosphodiesterase 100% identity with Seq.ID:2 nt.1-295 reverse orientation XP002105162
  • BEAVO J.A.: "Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms" PHYSIOLOGICAL REVIEWS, vol. 75, no. 4, 1 October 1995 (1995-10-01), pages 725-748, XP002034532
  • LOUGHNEY K. AND FERGUSON K.: "Identification and quantification of PDE isoenzymes and subtypes by molecular biological methods" PHOSPHODIESTERASE INHIBITORS. EDS: SCHUDT C., DENT G., RABE K.F.; PUB: ACADEMIC LONDON UK,1996, pages 1-19, XP002105161
  • HETMAN J.M. ET AL.: "Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 97, no. 1, 4 January 2000 (2000-01-04), pages 472-476, XP002134917 ISSN: 0027-8424
  • DATABASE EMBL 15 July 1998 (1998-07-15), "High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A" XPQ13946
  • MICHAELI T. ET AL.: "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae" THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 17, 15 June 1993 (1993-06-15), pages 12925-12932,
  • HAN P. ET AL.: "Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart" THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 26, 27 June 1997 (1997-06-27), pages 16152-16157,
  • BLOOM T.J. AND BEAVO J.A.: "Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 93, November 1996 (1996-11), pages 14188-14192,
  • DATABASE EMBL MICHAELI T.: "Homo sapiens cAMP phosphodiesterase PDE7 (PDE7A1) mRNA, complete cds." XPL12052
  • DATABASE EMBL 20 September 1996 (1996-09-20), BLOOM T.J. AND BEAVO J.A.: "Mus musculus cyclic nucleotide phosphodiesterase PDE7A2 (MMPDE7A) mRNA, complete cds." XPU68171
  • GARDNER C. ET AL.: "Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide Phosphodiesterase" BIOCHEMICAL AND BIOPHYSICAL ESEARCH COMMUNICATIONS, vol. 272, 2000, pages 186-192,
   
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