(19)

(11)

EP 1 019 027 A1

(12)

(43) Date of publication: 19.07.2000 Bulletin 2000/29 (21) Application number: 98908535.2 (22) Date of filing: 12.02.1998

(51) International Patent Classification (IPC)7: A61K 9/14, A61K 38/00, A61K 38/18, A61K 38/39, C07K 1/00, C07K 14/78, C07K 14/475, C07K 14/495, C07C 53/08, A61F 13/00 (86) International application number: PCT/US9802/751 (87) International publication number: WO 9835/653 (20.08.1998 Gazette 1998/33)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.02.1997 US 37071 P (71) Applicants: Benedict, James A. Arvada, CO 80007 (US) Damien, Christopher J. Denver, CO 80209 (US)	(72) Inventor: DAMIEN, Christopher, J. Denver, CO 80209 (US) (74) Representative: Herrmann-Trentepohl, Werner, Dipl.-Ing.  PatentanwälteHerrmann-TrentepohlGrosse - Bockhorni & PartnerForstenrieder Allee 59 81476 München 81476 München (DE)