(19)

(11)

EP 1 019 046 A1

(12)

(43) Date of publication: 19.07.2000 Bulletin 2000/29 (21) Application number: 98920926.7 (22) Date of filing: 29.04.1998

(51) International Patent Classification (IPC)7: A61K 31/41, A61K 31/415, A61K 31/42, A61K 31/425, A61K 31/495, A61K 31/50, A61K 31/505, A61K 31/53, A61K 31/555, C07D 231/04, C07D 231/06, C07D 231/10, C07D 233/02, C07D 233/04, C07D 233/54, C07D 233/96, C07D 237/00, C07D 237/02, C07D 239/02, C07D 241/02, C07D 249/08, C07D 251/00, C07D 253/00, C07D 257/08, C07D 257/12 (86) International application number: PCT/US9808/740 (87) International publication number: WO 9848/799 (05.11.1998 Gazette 1998/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 29.04.1997 US 45067 (71) Applicant: Smithkline Beecham Philadelphia, PA 19103 (US)	(72) Inventors: HALBERT, Stacie, Marie Harleysville, PA 19438 (US) MICHAUD, Evelyne Norristown, PA 19401 (US) THOMPSON, Scott, Kevin Phoenixville, PA 19460 (US) VEBER, Daniel, Frank Ambler, PA 19002 (US) (74) Representative: Rutter, Keith, Dr.  SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)