(19)

(11)

EP 1 019 081 A2

(12)

(88) Date of publication A3: 17.06.1999 (43) Date of publication: 19.07.2000 Bulletin 2000/29 (21) Application number: 98950816.3 (22) Date of filing: 29.09.1998

(51) International Patent Classification (IPC)7: A61K 38/18, C12N 5/06, A61K 38/21 (86) International application number: PCT/US9820/591 (87) International publication number: WO 9916/460 (08.04.1999 Gazette 1999/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.09.1997 US 60533 P (71) Applicant: DUKE UNIVERSITY Durham,North Carolina 27708-0083 (US)	(72) Inventors: MATTHEW, William, D. Durham, NC 27707 (US) STRITTMATTER, Warren, J. Durham, NC 27707 (US) GUTMAN, Catherine, R. Durham, NC 27701 (US) FULLERTON, Stephanie, M. Durham, NC 27705 (US) (74) Representative: Horner, Martin Grenville et al Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AEScotland Glasgow G1 3AEScotland (GB)