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(11)

EP 1 019 411 A1

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(43) Date of publication: 19.07.2000 Bulletin 2000/29 (21) Application number: 98933069.1 (22) Date of filing: 02.07.1998

(51) International Patent Classification (IPC)7: C07D 495/08, C07D 207/12 (86) International application number: PCT/US9813/738 (87) International publication number: WO 9902/531 (21.01.1999 Gazette 1999/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 09.07.1997 US 52032 P 13.05.1998 GB 9810184 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)

(72) Inventors: BRANDS, Karel, M., J. Rahway, NJ 07065 (US) WILLIAMS, John, M. Rahway, NJ 07065 (US) DOLLING, Ulf, H. Rahway, NJ 07065 (US) JOBSON, Ronald, B. Rahway, NJ 07065 (US) DAVIES, Anthony, J. Rahway, NJ 07065 (US) COTTRELL, Ian, F. Rahway, NJ 07065 (US) CAMERON, Mark Rahway, NJ 07065 (US) ASHWOOD, Michael, S. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James et al European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)