(19)

(11)

EP 1 019 497 A1

(12)

(43) Date of publication: 19.07.2000 Bulletin 2000/29 (21) Application number: 98930352.4 (22) Date of filing: 17.06.1998

(51) International Patent Classification (IPC)7: C12N 15/11, C12N 9/00, C07H 21/00, A61K 31/70 // C12Q1:68 (86) International application number: PCT/US9812/663 (87) International publication number: WO 9858/058 (23.12.1998 Gazette 1998/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.06.1997 US 878640 (71) Applicant: RIBOZYME PHARMACEUTICALS, INC. Boulder, CO 80301-5411 (US)	(72) Inventors: LUDWIG, Janos D-37085 Göttingen (DE) SPROAT, Brian, S. D-37139 Adelebsen (DE) (74) Representative: Moon, Donald Keith  BREWER & SONQuality HouseQuality CourtChancery Lane London WC2A 1HT London WC2A 1HT (GB)