(19)

(11)

EP 1 019 502 A2

(12)

(88) Date of publication A3: 15.04.1999 (43) Date of publication: 19.07.2000 Bulletin 2000/29 (21) Application number: 98939199.0 (22) Date of filing: 04.08.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 16/28, C12N 15/62, C12N 15/63, C12P 21/08, A61K 38/16 (86) International application number: PCT/US9816/202 (87) International publication number: WO 9907/738 (18.02.1999 Gazette 1999/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.08.1997 US 54869 P (71) Applicants: REGENERON PHARMACEUTICALS, INC. Tarrytown, NY 10591-6707 (US) THE PROCTER & GAMBLE COMPANY Cincinnati,Ohio 45202 (US)	(72) Inventors: MASIAKOWSKI, Piotr, J. Pleasant Valley, NY 12569 (US) MORRIS, Jodi New City, NY 10956 (US) VALENZUELA, David, M. Yorktown Heights, NY 10598 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)