(19)

(11)

EP 1 021 193 A1

(12)

(43) Date of publication: 26.07.2000 Bulletin 2000/30 (21) Application number: 98948468.8 (22) Date of filing: 23.09.1998

(51) International Patent Classification (IPC)7: A61K 31/595 (86) International application number: PCT/US9819/862 (87) International publication number: WO 9916/452 (08.04.1999 Gazette 1999/14)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.09.1997 US 60173 07.05.1998 US 73723 07.05.1998 US 74565 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94607-5200 (US)	(72) Inventors: NORMAN, Anthony, W. Riverside, CA 92504 (US) OKAMURA, William, H. Riverside, CA 92507 (US) (74) Representative: Sexton, Jane Helen et al J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)