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(11)

EP 1 021 445 A1

(12)

(43) Date of publication: 26.07.2000 Bulletin 2000/30 (21) Application number: 97939843.5 (22) Date of filing: 08.09.1997

(51) International Patent Classification (IPC)7: C07D 487/04, A61K 31/395 (86) International application number: PCT/US9715/831 (87) International publication number: WO 9811/108 (19.03.1998 Gazette 1998/11)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 12.09.1996 US 26184 P 22.11.1996 GB 9624277 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: CAMA, Lovji, D. Rahway, NJ 07065 (US) WILKENING, Robert, R. Rahway, NJ 07065 (US) RATCLIFFE, Ronald, W. Rahway, NJ 07065 (US) BLIZZARD, Timothy, A. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)