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(11)

EP 1 021 462 A1

(12)

(43) Date of publication: 26.07.2000 Bulletin 2000/30 (21) Application number: 98956094.1 (22) Date of filing: 06.10.1998

(51) International Patent Classification (IPC)7: C07K 14/435, C07K 14/705, C09K 11/06, G01N 33/53, G01N 33/566 (86) International application number: PCT/US9821/049 (87) International publication number: WO 9918/124 (15.04.1999 Gazette 1999/15)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.10.1997 US 61385 P (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: CUMMINGS, Richard, T. Rahway, NJ 07065 (US) HERMES, Jeffrey, D. Rahway, NJ 07065 (US) MOLLER, David, E. Rahway, NJ 07065 (US) ZHOU, Gaochao Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)