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(11)

EP 1 021 538 A1

(12)

(43) Date of publication: 26.07.2000 Bulletin 2000/30 (21) Application number: 98952143.0 (22) Date of filing: 07.10.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/31, C12N 15/62, C12N 1/19, C07K 14/47, C07K 14/395, C12Q 1/02, C12Q 1/68, G01N 33/50 (86) International application number: PCT/US9821/168 (87) International publication number: WO 9918/211 (15.04.1999 Gazette 1999/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.10.1997 US 946298 (71) Applicant: CADUS PHARMACEUTICAL CORPORATION Tarrytown, NY 10591-6705 (US)

(72) Inventors: BROACH, James, R. Princeton, NJ 08540 (US) MANFREDI, John, P. Ossining, NY 10562 (US) PAUL, Jeremy, I. Nyack, NY 10690 (US) TRUEHEART, Joshua South Nyack, NY 10960 (US) KLEIN, Christine, A. Ossining, NY 10562 (US) MURPHY, Andrew, J., M. Montclair, NJ 07043 (US) XU, Jun Ossining, NY 10562 (US) BENEGAL, Anupama, N. River Edge, NJ 07661 (US) (74) Representative: Hutchins, Michael Richard et al FRY HEATH & SPENCEThe Old College53 High Street HorleySurrey RH6 7BN HorleySurrey RH6 7BN (GB)