(19)

(11)

EP 1 023 065 A1

(12)

(43) Date of publication: 02.08.2000 Bulletin 2000/31 (21) Application number: 98948983.6 (22) Date of filing: 27.08.1998

(51) International Patent Classification (IPC)7: A61K 31/43, A61K 9/16, A61K 9/20 (86) International application number: PCT/EP9805/902 (87) International publication number: WO 9911/261 (11.03.1999 Gazette 1999/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.08.1997 EP 97202651 (71) Applicant: DSM N.V. 6411 TE Heerlen (NL)	(72) Inventor: GROENENDAAL, Jan, Willem NL-2611 EE Delft (NL) (74) Representative: Visser-Luirink, Gesina, Dr. et al DSM Patents & TrademarksOffice DelftP.O. Box 1 2600 MA Delft 2600 MA Delft (NL)