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EP 1 023 281 A1

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(43) Date of publication: 02.08.2000 Bulletin 2000/31 (21) Application number: 98904970.5 (22) Date of filing: 03.02.1998

(51) International Patent Classification (IPC)7: C07D 321/00, C07D 311/92, A01N 43/16, A01N 43/02, A61K 31/35, A61K 31/335, C07D 407/10 // (C07D407/10, 321:00, 309:00) (86) International application number: PCT/US9802/292 (87) International publication number: WO 9834/932 (13.08.1998 Gazette 1998/32)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.02.1997 US 36902 P 14.04.1997 GB 9707492 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)

(72) Inventors: BILLS, Gerald, F. Rahway, NJ 07065 (US) LINGHAM, Russell, B. Rahway, NJ 07065 (US) SHAFIEE, Ali Rahway, NJ 07065 (US) SILVERMAN, Keith, C. Rahway, NJ 07065 (US) SINGH, Sheo, Bux Rahway, NJ 07065 (US) ZINK, Deborah, L. Rahway, NJ 07065 (US) PELAEZ, Fernando E-28027 Madrid (ES) TERAN, Ana M. E-28027 Madrid (ES) (74) Representative: Thompson, John Dr.  Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB) (56) References cited: :