(19)

(11)

EP 1 023 324 A1

(12)

(43) Date of publication: 02.08.2000 Bulletin 2000/31 (21) Application number: 97944656.4 (22) Date of filing: 15.10.1997

(51) International Patent Classification (IPC)7: C07K 14/815, A61K 38/58 (86) International application number: PCT/CA9700/745 (87) International publication number: WO 9919/356 (22.04.1999 Gazette 1999/16)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: NATIONAL RESEARCH COUNCIL OF CANADA Ottawa,Ontario K1A OR6 (CA)	(72) Inventors: KONISHI, Yasuo Kirkland, Quebec H9J 1K8 (CA) SLON, Jacek Montreal, Quebec H4P 2G6 (CA) (74) Representative: Jacob, Reuben Ellis  Edward Evans & Co.,Clifford's Inn,Fetter Lane London EC4A 1BX London EC4A 1BX (GB)