(19)

(11)

EP 1 023 434 A1

(12)

(43) Date of publication: 02.08.2000 Bulletin 2000/31 (21) Application number: 98947131.3 (22) Date of filing: 18.09.1998

(51) International Patent Classification (IPC)7: C12N 1/00, C12N 1/20, C12Q 1/02, C12Q 1/22, G01N 33/53 (86) International application number: PCT/US9819/505 (87) International publication number: WO 9914/311 (25.03.1999 Gazette 1999/12)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 18.09.1997 US 59218 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: COLEMAN, Kenneth Chester Springs, PA 19425 (US) CRITCHLEY, Ian, A. Exton, PA 19341 (US) (74) Representative: Connell, Anthony Christopher  SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)