(19)

(11)

EP 1 023 438 A1

(12)

(43) Date of publication: 02.08.2000 Bulletin 2000/31 (21) Application number: 98945082.0 (22) Date of filing: 23.09.1998

(51) International Patent Classification (IPC)7: C12N 9/28 (86) International application number: PCT/DK9800/411 (87) International publication number: WO 9915/636 (01.04.1999 Gazette 1999/13)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 24.09.1997 DK 110097 07.10.1997 US 61559 P (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: JOERGENSEN, Steen, Troels DK-2880 Bagsvaerd (DK) FRANDSEN, Torben, Peter DK-2880 Bagsvaerd (DK) ANDERSEN, Carsten DK-2880 Bagsvaerd (DK)