(19)

(11)

EP 1 024 804 A1

(12)

(43) Date of publication: 09.08.2000 Bulletin 2000/32 (21) Application number: 98918680.4 (22) Date of filing: 23.04.1998

(51) International Patent Classification (IPC)7: A61K 31/355, A61K 31/34, A61K 31/075, A61K 31/445, A61K 31/495, A61K 31/50 (86) International application number: PCT/US9808/269 (87) International publication number: WO 9850/028 (12.11.1998 Gazette 1998/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.05.1997 US 45405 P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)	(72) Inventors: GREGG, Richard, E. Pennington, NJ 08534 (US) WETTERAU, John, R., II Langhorne, PA 19047 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)