(19)

(11)

EP 1 024 828 A1

(12)

(43) Date of publication: 09.08.2000 Bulletin 2000/32 (21) Application number: 97912875.8 (22) Date of filing: 17.10.1997

(51) International Patent Classification (IPC)7: A61K 39/09, C12N 5/10, C12N 9/00, C12N 15/31, C12Q 1/14, C12P 21/00, C07K 14/315, C07K 16/12 (86) International application number: PCT/US9719/173 (87) International publication number: WO 9920/307 (29.04.1999 Gazette 1999/17)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: LAWLOR, Elizabeth, J. Malvern, PA 19355 (US) JAWORSKI, Deborah, Dee Norristown, PA 19403 (US) WANG, Min Blue Bell, PA 19422 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)