(19)

(11)

EP 1 025 214 A2

(12)

(88) Date of publication A3: 00.00.0000 (43) Date of publication: 09.08.2000 Bulletin 2000/32 (21) Application number: 98955572.7 (22) Date of filing: 22.10.1998

(51) International Patent Classification (IPC)7: C12N 9/64, A23C 19/02, C07K 1/14 (86) International application number: PCT/EP9807/223 (87) International publication number: WO 9921/974 (06.05.1999 Gazette 1999/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.10.1997 EP 97203308 (71) Applicant: DSM N.V. 6411 TE Heerlen (NL)	(72) Inventors: ROBERS, Hendrik, Jan NL-2624 XP Delft (NL) WEBBERS, Josephus, Johannes, Paulus NL-3146 BV Maassluis (NL) (74) Representative: Matulewicz, Emil Rudolf Antonius  DSM- Patents & Trademarks (994-0760),P.O. Box 1 2600 MA Delft 2600 MA Delft (NL)