(19)

(11)

EP 1 027 042 A1

(12)

(43) Date of publication: 16.08.2000 Bulletin 2000/33 (21) Application number: 98948279.9 (22) Date of filing: 16.09.1998

(51) International Patent Classification (IPC)7: A61K 31/33, A61K 31/495, A61K 31/50, A61K 31/53, A61K 31/535, A61K 31/54, A61K 31/55, C07D 237/26, C07D 239/70, C07D 241/36, C07D 243/12 (86) International application number: PCT/US9819/315 (87) International publication number: WO 9918/951 (22.04.1999 Gazette 1999/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.09.1997 US 60823 P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)	(72) Inventors: DING, Charles, Z. Plainsboro, NJ 08536 (US) HUNT, John, T. Princeton, NJ 08540 (US) LEFTHERIS, Katerina Skillman, NJ 08558 (US) BHIDE, Rajeev, S. Langhorne, PA 19047 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)