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EP 1 027 046 A1

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(43) Date of publication: 16.08.2000 Bulletin 2000/33 (21) Application number: 98954019.0 (22) Date of filing: 27.10.1998

(51) International Patent Classification (IPC)7: A61K 31/405, A61K 31/445, A61K 31/535, C07D 207/08, C07D 207/09, C07D 209/14, C07D 295/104, C07D 239/06, C07D 401/06, C07D 401/10, C07D 401/14, C07D 413/06, C07D 413/08 (86) International application number: PCT/US9822/799 (87) International publication number: WO 9921/553 (06.05.1999 Gazette 1999/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.10.1997 US 63305 P 07.05.1998 GB 9809789 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: CHU, Lin Rahway, NJ 07065 (US) GOULET, Mark, T. Rahway, NJ 07065 (US) WALSH, Thomas, F. Rahway, NJ 07065 (US) WITKIN, Stephanie, L. Rahway, NJ 07065 (US) WYVRATT, Matthew, J. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)