(19)

(11)

EP 1 027 059 A2

(12)

(88) Date of publication A3: 08.07.1999 (43) Date of publication: 16.08.2000 Bulletin 2000/33 (21) Application number: 98953989.5 (22) Date of filing: 26.10.1998

(51) International Patent Classification (IPC)7: A61K 31/70, A61K 31/47, A61K 39/395, G01N 33/50 (86) International application number: PCT/US9822/655 (87) International publication number: WO 9921/574 (06.05.1999 Gazette 1999/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.10.1997 US 63624 P (71) Applicant: CREATIVE BIOMOLECULES, INC. Hopkinton, MA 01748 (US)	(72) Inventors: CHARETTE, Marc, F. Needham, MA 02192 (US) RUEGER, David, C. Southborough, MA 01772 (US) HIGGINS, Dennis Amherst, NY 14226 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)