(19)

(11)

EP 1 027 071 A2

(12)

(88) Date of publication A3: 05.08.1999 (43) Date of publication: 16.08.2000 Bulletin 2000/33 (21) Application number: 98955231.0 (22) Date of filing: 02.11.1998

(51) International Patent Classification (IPC)7: A61K 39/39, A61K 9/127, A61K 38/20, A61K 39/145, A61K 39/00 // C07K14:545, A61K39:145, A61K38:20 (86) International application number: PCT/US9823/313 (87) International publication number: WO 9922/763 (14.05.1999 Gazette 1999/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.10.1997 US 962407 (71) Applicant: Cistron Biotechnology Inc. Pine Brook, NJ 07058 (US)	(72) Inventors: DONDERO, Richard, S. Riverdale, NJ 07457 (US) GALTON, Bruce, C. Madison, NJ 07940 (US) CASEY, Leslie, S. New York, NY 10024 (US) (74) Representative: Perry, Robert Edward et al GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)