(19)

(11)

EP 1 027 337 A1

(12)

(43) Date of publication: 16.08.2000 Bulletin 2000/33 (21) Application number: 98944735.4 (22) Date of filing: 03.09.1998

(51) International Patent Classification (IPC)7: C07D 223/20, A61K 31/55 (86) International application number: PCT/US9818/379 (87) International publication number: WO 9911/626 (11.03.1999 Gazette 1999/10)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 04.09.1997 US 57529 P 29.10.1997 US 63520 P (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HEERDING, Dirk, A. Malvern, PA 19355 (US) SAMANEN, James, M. Phoenixville, PA 19460 (US) (74) Representative: Valentine, Jill Barbara et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)