(19)

(11)

EP 1 027 352 A1

(12)

(43) Date of publication: 16.08.2000 Bulletin 2000/33 (21) Application number: 98953736.0 (22) Date of filing: 19.10.1998

(51) International Patent Classification (IPC)7: C07D 477/14, A61K 31/55, A61K 31/495 (86) International application number: PCT/US9822/110 (87) International publication number: WO 9920/627 (29.04.1999 Gazette 1999/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.10.1997 US 63031 P 25.03.1998 GB 9806431 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: CAMA, Lovji, D. Rahway, NJ 07065 (US) RATCLIFFE, Ronald, W. Rahway, NJ 07065 (US) WILKENING, Robert, R. Rahway, NJ 07065 (US) WILDONGER, Kenneth, J. Rahway, NJ 07065 (US) SUN, Wanying Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic  Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)