USES OF THE WNT-1 INDUCED SECRETED POLYPEPTIDE WISP-1

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EP 1 027 437 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	29.10.2008 Bulletin 2008/44

(45)	Mention of the grant of the patent:
	27.08.2008 Bulletin 2008/35

(21)	Application number: 98956340.8

(22)	Date of filing: 29.10.1998

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International Patent Classification (IPC):

C12N 15/12^(2006.01)
C12N 15/62^(2006.01)

C07K 14/47^(2006.01)
C07K 16/18^(2006.01)

(86)	International application number:
	PCT/US1998/022991

(87)	International publication number:
	WO 1999/021998 (00.00.0000 Gazette 1999/18)

(54)	USES OF THE WNT-1 INDUCED SECRETED POLYPEPTIDE WISP-1 VERWENDUNG DES WNT-1 INDUZIERTEN SEKRETIERTEN POLYPEPTIDS WISP-1 UTILISATION DU POLYPEPTIDE SECRETE INDUITE PAR WNT-1 WISP-1

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

29.10.1997 US 63704 P
04.02.1998 US 73612 P
14.04.1998 US 81695 P

(43)	Date of publication of application:
	16.08.2000 Bulletin 2000/33

(60)	Divisional application:
	08012474.6

(73)	Proprietor: Genentech, Inc.
	South San Francisco CA 94080-4990 (US)

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Inventors:

BOTSTEIN, David, A.
Belmont, CA 94002 (US)
COHEN, Robert, L.
San Mateo, CA 94402 (US)
GURNEY, Austin, L.
Belmont, CA 94002 (US)
HILLAN, Kenneth
San Francisco, CA 94114 (US)
LAWRENCE, David, A.
San Francisco, CA 94122 (US)
LEVINE, Arnold, J.
New York, NY 10021 (US)
PENNICA, Diane
Burlingame, CA 94010 (US)
ROY, Margaret, Ann
San Francisco, CA 94123 (US)
GODDARD, Audrey
San Francisco, CA 94131 (US)
WOOD, William, I.
Hillsborough, CA 94010 (US)

(74)	Representative: Kiddle, Simon John et al
	Mewburn Ellis LLP 23 Kingsway London WC2B 6HP 23 Kingsway London WC2B 6HP (GB)

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References cited: :

WO-A-98/21236

DATABASE EMBL - EMEST1 Entry Aa592984, Acc.no. AA592984, 24 September 1997 STRAUSBERG, R.: "nn03e01.s1 NCI_CGAP_Pr4.1 Homo sapiens cDNA clone IMAGE:1076664 similar to TR:G984956 G984956 CONNECTIVE TISSUE GROWTH FACTOR" XP002094092
DATABASE EMBL - EMHUM1 Entry Hs142l7, Acc.no. Z99289, 17 September 1997 TUBBY B.: "Homo sapiens DNA sequence from PAC 142L7 on chromosome 6q21. Contains a...Connective tissue growth factor (NOV, GIG) LIKE gene,..." XP002094093
OEMAR, B.S. ET AL.: "Connective tissue growth factor - friend or foe?" ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 17, no. 8, August 1997, pages 1483-9, XP002094090 cited in the application
DATABASE EMBL - EMEST10 Entry HS01627, Acc.no T55016, 28 February 1995 HILLIER, L. ET AL.: "yb42e03.r1 Homo sapiens cDNA clone 73852 5'" XP002094094
DATABASE EMBL - EMEST18 Entry Hszz82583, Acc.no. AA377456, 18 April 1997 ADAMS, M.D. ET AL.: "EST90040 Synovial membrane Homo sapiens cDNA 5' end." XP002094095 -& ADAMS, M.D. ET AL.: "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" NATURE, vol. 377, 1995, pages 3-17, XP002042918
HASHIMOTO, Y. ET AL.: "Expression of the Elm1 gene, a novel gene of the CCN (Connective tissue groath factor, Cyr61/Cef10, and neuroblastoma overexpressed gene) family, sppresses in vivo tumor growth and metastasis of K-1735 murine melanoma cells." JOURNAL OF EXPERIMENTAL MEDICINE, vol. 187, no. 3, 2 February 1998, pages 289-96, XP002094091 cited in the application
ZHANG, R. ET AL.: "Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation" MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 10, October 1998, pages 6131-41, XP002094139 cited in the application

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).