(19)

(11)

EP 1 029 037 A1

(12)

(43) Date of publication: 23.08.2000 Bulletin 2000/34 (21) Application number: 98937782.5 (22) Date of filing: 11.08.1998

(51) International Patent Classification (IPC)7: C12N 15/00, A01K 67/027, C12N 5/10 (86) International application number: PCT/IT9800/231 (87) International publication number: WO 9911/772 (11.03.1999 Gazette 1999/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.08.1997 IT MI971972 (71) Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE 00185 Roma (IT)

(72) Inventors: RONCUCCI, Sylvie 20159 Milano (IT) SACCO, Maria, Grazia-Institute of Advanced Biomedi I-20131 Milano (IT) ZECCA, Luigi-Institute of Advanced Biomedical Tech I-20131 Milano (IT) BROMLEY, Peter-Institute of Advanced Biomedical Te I-20131 Milano (IT) CLERICI, Libero, A.-Joint Research Center I-21027 Ispra (IT) VEZZONI, Paolo-Institute of Advanced Biomedical Te I-20131 Milano (IT) (74) Representative: Minoja, Fabrizio, Dr. et al Bianchetti Bracco Minoja S.r.l.Via Rossini, 8 20122 Milano 20122 Milano (IT)