(19)

(11)

EP 1 029 042 A1

(12)

(43) Date of publication: 23.08.2000 Bulletin 2000/34 (21) Application number: 98953857.4 (22) Date of filing: 21.10.1998

(51) International Patent Classification (IPC)7: C12N 15/11, C12N 15/63, C12N 15/85, C07K 14/00, C07K 16/00, C07H 21/04, G06F 19/00, C12Q 1/68, C12Q 1/00, G01N 33/53, G01N 33/567 (86) International application number: PCT/US9822/321 (87) International publication number: WO 9920/754 (29.04.1999 Gazette 1999/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.10.1997 US 63138 P 27.02.1998 US 76172 P (71) Applicant: WASHINGTON UNIVERSITY St. Louis, MO 63130 (US)	(72) Inventors: SALKOFF, Lawrence Clayton, MO 63105 (US) SCHREIBER, Matthew Clayton, MO 63105 (US) SILVIA, Chris Durham, NC 27712 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)