(19)
(11) EP 1 030 679 A1

(12)

(43) Date of publication:
30.08.2000 Bulletin 2000/35

(21) Application number: 98957325.8

(22) Date of filing: 15.10.1998
(51) International Patent Classification (IPC)7: A61K 38/08, A61K 38/10, A61K 38/16
(86) International application number:
PCT/US9821/800
(87) International publication number:
WO 9920/295 (29.04.1999 Gazette 1999/17)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 17.10.1997 US 62274 P

(71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Philadelphia, Pennsylvania 19104 (US)

(72) Inventors:
  • CINES, Douglas
    Wynnewood, PA 19096 (US)
  • HIGAZI, Abd, Al-Roof
    Bala Cynwyd, PA 19004 (US)

(74) Representative: Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät 
Maximilianstrasse 58
80538 München
80538 München (DE)

   


(54) COMPOSITIONS AND METHODS FOR PROMOTING INTERNALIZATION AND DEGRADATION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR