(19)

(11)

EP 1 030 865 A2

(12)

(88) Date of publication A3: 15.07.1999 (43) Date of publication: 30.08.2000 Bulletin 2000/35 (21) Application number: 98957483.5 (22) Date of filing: 12.11.1998

(51) International Patent Classification (IPC)7: C07K 14/00 (86) International application number: PCT/US9823/240 (87) International publication number: WO 9925/734 (27.05.1999 Gazette 1999/21)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 13.11.1997 US 65392 P (71) Applicants: SCHERING CORPORATION KenilworthNew Jersey 07033 (US) Napolitano, Monica 00167 Rome (IT)	(72) Inventors: SOTO-TREJO, Hortensia Sunnyvale, CA 94086 (US) HETRICK, Joseph, A. Plainsboro, NJ 08536 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)