(19)

(11)

EP 1 031 034 A1

(12)

(43) Date of publication: 30.08.2000 Bulletin 2000/35 (21) Application number: 98957464.5 (22) Date of filing: 02.11.1998

(51) International Patent Classification (IPC)7: G01N 33/20 (86) International application number: PCT/US9823/198 (87) International publication number: WO 9924/830 (20.05.1999 Gazette 1999/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.11.1997 US 64779 P (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY Princeton, NJ 08543-4000 (US)	(72) Inventors: ARONSON, Jeffrey, K. Oxford OX2 7AU (GB) DE SILVA, Asita, H. Kohuwala (LK) GRAHAME-SMITH, David, G. Oxford OX1 5DY (GB) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)