(19)

(11)

EP 1 031 135 A1

(12)

(43) Date of publication: 30.08.2000 Bulletin 2000/35 (21) Application number: 98957883.6 (22) Date of filing: 12.11.1998

(51) International Patent Classification (IPC)7: G10K 11/00, G10K 11/20 (86) International application number: PCT/US9824/152 (87) International publication number: WO 9924/967 (20.05.1999 Gazette 1999/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.11.1997 US 65111 P (71) Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Rockville, MD 20852-3804 (US)	(72) Inventors: WEN, Han Gaithersburg, MD 20878 (US) BENNETT, Eric, B. Gaithersburg, MD 20877 (US) (74) Representative: Grund, Martin, Dr. et al Holbeinstrasse 5 81679 München 81679 München (DE)