(19)

(11)

EP 1 032 384 A1

(12)

(43) Date of publication: 06.09.2000 Bulletin 2000/36 (21) Application number: 98953737.8 (22) Date of filing: 19.10.1998

(51) International Patent Classification (IPC)7: A61K 31/40, C07D 477/14 (86) International application number: PCT/US9822/111 (87) International publication number: WO 9920/270 (29.04.1999 Gazette 1999/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 23.10.1997 US 63241 P 06.04.1998 GB 9807362 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: DININNO, Frank, P. Rahway, NJ 07065 (US) HAMMOND, Milton, L. Rahway, NJ 07065 (US) (74) Representative: Hiscock, Ian James et al European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)