(19)
(11) EP 1 032 385 A1

(12)

(43) Date of publication:
06.09.2000 Bulletin 2000/36

(21) Application number: 98960381.6

(22) Date of filing: 20.11.1998
(51) International Patent Classification (IPC)7A61K 31/40, A61K 31/015, C07C 13/465
(86) International application number:
PCT/US9824/968
(87) International publication number:
WO 9926/624 (03.06.1999 Gazette 1999/22)
(84) Designated Contracting States:
AT BE CH DE ES FR GB IE IT LI LU NL PT SE

(30) Priority: 20.11.1997 US 975595
23.09.1998 US 159336
23.09.1998 US 159331

(71) Applicants:
  • CHILDREN'S MEDICAL CENTER CORPORATION
    BostonMassachusetts 02115 (US)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Cambridge, MA 02138 (US)

(72) Inventors:
  • BRUGNARA, Carlo
    Newton Highlands, MA 02161 (US)
  • HALPERIN, Jose
    Brookline, MA 02146 (US)
  • BELLOT, Emile, M., Jr.
    Beverly, MA 01915 (US)
  • FROIMOWITZ, Mark
    Newton Centre, MA 02159 (US)
  • LOMBARDY, Richard, John
    Waltham, MA 02154 (US)
  • CLIFFORD, John, J.
    Bedford, MA 01730 (US)
  • GAO, Ying-Duo
    Iselin, NJ 08830 (US)
  • HAIDAR, Reem, M.
    Malden, MA 02148 (US)
  • KELLEHER, Eugene, W.
    Somerville, MA 02114 (US)
  • KHER, Falguni, M.
    Chelmsford, MA 01824 (US)
  • MOUSSA, Adel, M.
    Burlington, MA 01803 (US)
  • SACHDEVA, Yesh, P.
    Concord, MA 01742 (US)
  • SUN, Minghua
    Cambridge, MA 02139 (US)
  • TAFT, Heather, N.
    Littleton, MA 01460 (US)
  • LENCER, Wayne, I.
    Jamaica Plain, MA 02130 (US)
  • ALPER, Seth
    Jamaica Plain, MA 02130 (US)

(74) Representative: Jump, Timothy John Simon et al
Venner Shipley & Co.20 Little Britain
London EC1A 7DH
London EC1A 7DH (GB)

   


(54) USE OF SUBSTITUTED DIPHENYL INDANONE, INDANE AND INDOLE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELLPROLIFERATION, DIARRHE AND SCOURS