(19)
(11) EP 1 032 394 A1

(12)

(43) Date of publication:
06.09.2000 Bulletin 2000/36

(21) Application number: 98960380.8

(22) Date of filing: 20.11.1998
(51) International Patent Classification (IPC)7A61K 31/55, C07D 223/20
(86) International application number:
PCT/US9824/967
(87) International publication number:
WO 9926/628 (03.06.1999 Gazette 1999/22)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB IE IT LI LU NL PT SE

(30) Priority: 20.11.1997 US 975594
23.09.1998 US 159333
23.09.1998 US 159337

(71) Applicants:
  • CHILDREN'S MEDICAL CENTER CORPORATION
    BostonMassachusetts 02115 (US)
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Cambridge, MA 02138 (US)

(72) Inventors:
  • BRUGNARA, Carlo
    Newton Highlands, MA 02161 (US)
  • HALPERIN, Jose
    Brookline, MA 02146 (US)
  • BELLOT, Emile, M., Jr.
    Beverly, MA 01915 (US)
  • FROIMOWITZ, Mark
    Newton Centre, MA 02159 (US)
  • LOMBARDY, Richard, John
    Waltham, MA 02154 (US)
  • CLIFFORD, John, J.
    Bedford, MA 01730 (US)
  • GAO, Ying-Duo
    Iselin, NJ 08830 (US)
  • HAIDAR, Reem, M.
    Malden, MA 02148 (US)
  • KELLEHER, Eugne, W.
    Somerville, MA 02114 (US)
  • KHER, Falguni, M.
    Chelmsford, MA 01824 (US)
  • MOUSSA, Adel, M.
    Burlington, MA 01803 (US)
  • SACHDEVA, Yesh, P.
    Concord, MA 01742 (US)
  • SUN, Minghua
    Cambridge, MA 02139 (US)
  • TAFT, Heather, N.
    Littleton, MA 01460 (US)
  • LENCER, Wayne, I.
    Jamaica Plain, MA 02130 (US)
  • ALPER, Seth
    Jamaica Plain, MA 02130 (US)

(74) Representative: Jump, Timothy John Simon et al
Venner Shipley & Co.20 Little Britain
London EC1A 7DH
London EC1A 7DH (GB)

   


(54) USE OF SUBSTITUTED 11-PHENYL-DIBENZAZEPINE COMPOUNDS FOR THE TREATMENT OR PREVENTION OF SICKLE CELL DISEASE, INFLAMMATORY DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION, DIARRHEA AND SCOUR