(19)

(11)

EP 1 032 413 A1

(12)

(43) Date of publication: 06.09.2000 Bulletin 2000/36 (21) Application number: 98960523.3 (22) Date of filing: 27.11.1998

(51) International Patent Classification (IPC)7: A61K 38/44, A61K 38/45, A23C 9/123 (86) International application number: PCT/US9825/315 (87) International publication number: WO 9927/953 (10.06.1999 Gazette 1999/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.11.1997 US 66969 P (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, WI 53705 (US)	(72) Inventors: FAHL, William, E. Madison, WI 53711 (US) LOO, Deborah Madison, WI 53705 (US) MANOHARAN, Herbert Madison, WI 53711 (US) (74) Representative: Cripps, Joanna Elizabeth et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)