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EP 1 032 652 A1

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(43) Date of publication: 06.09.2000 Bulletin 2000/36 (21) Application number: 98960328.7 (22) Date of filing: 20.11.1998

(51) International Patent Classification (IPC)7: C12N 5/10, C12N 15/09, C12N 15/11, C12N 15/12, C12N 15/63, C07K 14/00, C07K 14/435, C07K 14/47 (86) International application number: PCT/US9824/808 (87) International publication number: WO 9927/079 (03.06.1999 Gazette 1999/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.11.1997 US 975936 26.10.1998 US 179034 (71) Applicant: Genetics Institute, Inc. Cambridge,Massachusetts 02410 (US)

(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) MCCOY, John, M. Reading, MA 01867 (US) LAVALLIE, Edward, R. Harvard, MA 01451 (US) COLLINS-RACIE, Lisa, A. Acton, MA 01720 (US) EVANS, Cheryl Beverly, MA 01915 (US) MERBERG, David Acton, MA 01720 (US) TREACY, Maurice Chestnut Hill, MA 02167 (US) SPAULDING, Vikki Billerica, MA 01821 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)