(19)
(11) EP 1 032 663 A1

(12)

(43) Date of publication:
06.09.2000 Bulletin 2000/36

(21) Application number: 98954606.4

(22) Date of filing: 20.11.1998
(51) International Patent Classification (IPC)7C12N 15/12, C12Q 1/68, C07K 14/47
(86) International application number:
PCT/GB9803/445
(87) International publication number:
WO 9927/090 (03.06.1999 Gazette 1999/22)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 20.11.1997 US 66241 P

(71) Applicants:
  • SMITHKLINE BEECHAM CORPORATION
    PhiladelphiaPennsylvania 19101 (US)
  • SMITHKLINE BEECHAM PLC
    Brentford,Middlesex TW8 9EP (GB)

(72) Inventors:
  • BERTRAM, Timothy,SmithKline Beecham Pharmaceut.
    WelwynHertfordshire AL6 9AR (GB)
  • BROWNE, Michael, J.SmithKline Beecham Pharmaceut.
    HarlowEssex CM19 5AW (GB)
  • BUGELSKI, Peter,SmithKline Beecham Pharmaceut.
    WelwynHertfordshire AL6 9AR (GB)
  • ENGLAND, PaulSmithKline Beecham Pharmaceuticals
    HarlowEssex CM19 5AW (GB)
  • MITCHELL, Ian,SmithKline Beecham Pharmaceuticals
    WelwynHertfordshire AL6 9AR (GB)
  • RUT, AndrewSmithKline Beecham Pharmaceuticals
    HarlowEssex CM19 5AW (GB)
  • MORGAN, Gwyn,SmithKline Beecham Pharmaceuticals
    WelwynHertfordshire AL6 9AR (GB)

(74) Representative: Blakey, Alison Jane et al
Smithkline Beecham,Corporate Intellectual Property,Two New Horizons Court
Brentford,Middlesex, TW8 9EP
Brentford,Middlesex, TW8 9EP (GB)

   


(54) METHODS FOR IDENTIFYING THE TOXIC/PATHOLOGIC EFFECT OF ENVIRONMENTAL STIMULI ON GENE TRANSCRIPTION