(19)

(11)

EP 1 032 665 A1

(12)

(43) Date of publication: 06.09.2000 Bulletin 2000/36 (21) Application number: 98956578.3 (22) Date of filing: 04.11.1998

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/47, C12N 5/10, C07K 16/18, C12Q 1/68 (86) International application number: PCT/US9823/524 (87) International publication number: WO 9925/828 (27.05.1999 Gazette 1999/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 19.11.1997 US 66157 P (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: CONKLIN, Darrell, C. Seattle, WA 98102 (US) BLUMBERG, Hal Seattle, WA 98103 (US) DEISHER, Theresa, A. Seattle, WA 98115 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)