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(11)

EP 1 032 682 A1

(12)

(43) Date of publication: 06.09.2000 Bulletin 2000/36 (21) Application number: 98955769.9 (22) Date of filing: 24.11.1998

(51) International Patent Classification (IPC)7: C12N 15/53, C12N 15/82, C12N 9/02, C12Q 1/26, G01N 33/53, A61K 38/44, C07K 16/40, C12P 7/64, C12N 5/10, A01H 5/00, C12Q 1/68 (86) International application number: PCT/GB9803/507 (87) International publication number: WO 9927/111 (03.06.1999 Gazette 1999/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV SI (30) Priority: 24.11.1997 GB 9724783 (71) Applicant: UNIVERSITY OF BRISTOL CliftonBristol BS8 1TH (GB)	(72) Inventor: NAPIER, Johnathan, A,I ACR-Long Ashton Research Long Ashton,Bristol BS41 9AF (GB) (74) Representative: Dean, John Paul et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)